High affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro, respectively; EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in vitro, respectively). Selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons. Brain penetrant in mice, rats and non-human primates.
JHU 37152
Catalog No.: GC50681Purity:>98.50%
JHU 37152 is a potent and brain-penetrant DREADD agonist, with EC50s of 5nM and 0.5nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2369979-67-7
10mM (in 1mL DMSO)In Stock
$31.00
1
5mgIn Stock
$18.00
1
10mgIn Stock
$28.00
1
25mgIn Stock
$56.00
1
50mgIn Stock
$87.00
1
100mgIn Stock
$142.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $31.00 | In Stock | 1 | |
| 5mg | $18.00 | In Stock | 1 | |
| 10mg | $28.00 | In Stock | 1 | |
| 25mg | $56.00 | In Stock | 1 | |
| 50mg | $87.00 | In Stock | 1 | |
| 100mg | $142.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Product Documents
Purity:>98.50%Appearance:A solid
Chemical Properties
CAS No.
2369979-67-7
SMILES
CCN1CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC(F)=C24)CC1
Molecular Formula
C19H20ClFN4
Molecular Weight
358.85
Solubility
DMSO|35.88|100|ethanol|35.88|100|
Storage
Store at RT
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
Reviews
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