15(S)-15-methyl Prostaglandin F2α ethyl amide

15(S)-15-methyl Prostaglandin F_2α has been shown to have potent uterine stimulant and abortifacient properties when administered intramuscularly to induce labor.^1,2 15(S)-15-methyl PGF_2α ethyl amide is a lipophilic analog of 15(S)-15-methyl PGF_2α methyl ester. Prostaglandin esters are generally hydrolyzed to the free acid upon in vivo administration, making the methyl esters useful prodrugs.³ Hydrolysis of prostaglandin amides in vivo is not thoroughly established.

1.Carlan, S.J., Gushwa, J.P., O'Brien, W.F., et al.Effect of intramuscular 15-methyl prostaglandin F2α after second-trimester deliveryObstet. Gynecol.895-9(1997) 2.Lindblom, B., KÄllfelt, B., Hahlin, M., et al.Local prostaglandin F2α injection for termination of ectopic pregnancyLancet776-777(1987) 3.Miller, W.L., and Sutton, M.J.Relative biological activity of certain prostaglandins and their enantiomersProstaglandins11(1)77-84(1976)