3'-Fluorothymidine-5'-triphosphate tetrasodium (3'-FdTTP tetrasodium) is a dTTP analog. 3'-Fluorothymidine-5'-triphosphate tetrasodium inhibits the T4 DNA polymerases competitively with dTTP. 3'-Fluorothymidine-5'-triphosphate tetrasodium inhibits DNA synthesis by T4 wild-type, L98 and CB121 DNA polymerase [1] [2].
References:
[1]. Schroeder C, et al. Inhibitor studies on phage T4 wild-type and mutant DNA polymerase. IV. The substrate analog 3'-fluorothymidine 5'-triphosphate. Z Allg Mikrobiol. 1980;20(10):657-62.
[2]. Schroeder C, et al.Inhibitor studies of phage T4 wild‐type and mutant DNA polymerases V. A summary of kinetic and inhibition data. Zeitschrift für allgemeine Mikrobiologie, 1981, 21(2): 141-155.
References:
[1]. Schroeder C, et al. Inhibitor studies on phage T4 wild-type and mutant DNA polymerase. IV. The substrate analog 3'-fluorothymidine 5'-triphosphate. Z Allg Mikrobiol. 1980;20(10):657-62.
[2]. Schroeder C, et al.Inhibitor studies of phage T4 wild‐type and mutant DNA polymerases V. A summary of kinetic and inhibition data. Zeitschrift für allgemeine Mikrobiologie, 1981, 21(2): 141-155.