AB-FUBINACA is an indazole-based synthetic cannabinoid (CB) that shows high affinity for the CB1 receptor (Ki = 0.9 nM). [1] [2] AB-FUBINACA metabolite 2B is an expected carboxy metabolite of AB-FUBINACA, based on the major metabolites produced from similar synthetic CBs in humans. [3] [4] AB-FUBINACA metabolite 2B is a single diastereomer, but its relative stereochemistry is unknown. The other diastereomer, AB-FUBINACA metabolite 2A, is sold as . The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Reference:
[1]. Uchiyama, N., Matsuda, S., Wakana, D., et al. New cannabimimetic indazole derivatives, N-(1-amino-3methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drugs in illegal products. Forensic Toxicol. 31(1), 93-100 (2013).
[2]. Buchler, I.P., Hayes, M.J., Hedge, S.G., et al. Indazole derivatives. 1-283 (2009).
[3]. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci. Int. 200(1-3), 141-147 (2010).
[4]. Moran, C.L., Le, V.H., Chimalakonda, K.C., et al. Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine. Anal. Chem. 83(11), 4228-4236 (2011).