Adrenomedullin (1-52) (human) (trifluoroacetate salt) (Synonyms: Adrenomedullin (1-52)-NH2) |
カタログ番号GC42740
One-Click Copy Product Info
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アドレノメドリン（1-52）は多様な生物学的活性を持つペプチドです。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Adrenomedullin (1-52) is a peptide with diverse biological activities. It belongs to the calcitonin family of peptides, which includes amylin , calcitonin gene-related peptide , and calcitonin . Adrenomedullin (1-52) is expressed in pheochromocytomas, adrenal medulla, heart, lung, and kidney as well as human umbilical vein endothelial cells (HUVECs) and in human glomerular epithelial and hematopoietic cell lines. In vivo, adrenomedullin (1-52) (10-3,000 ng per animal) reverses increases in lobar arterial pressure induced by U-46619 in a dose-dependent manner in cats but has no effect on basal lobar arterial pressure or systemic arterial pressure. It reduces mechanical ventilation-induced lung injury and sepsis as well as liver and gut injury induced by ventilator-induced lung injury in a mouse model of pneumococcal pneumonia infection. Adrenomedullin (1-52) improves survival and inhibits cardiac tissue damage induced by doxorubicin in mice. Adrenomedullin (1-52) also reduces hyperoxia-induced right ventricular hypertrophy and artery thickness in a rat model of bronchopulmonary dysplasia.
| Cas No. | SDF | ||
| 同義語 | Adrenomedullin (1-52)-NH2 | ||
| Formula | C264H406N80O77S3•XCF3COOH | M.Wt | 6028.7 |
| 溶解度 | Water: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 165.9 μL | 829.4 μL | 1.6587 mL |
| 5 mM | 33.2 μL | 165.9 μL | 331.7 μL |
| 10 mM | 16.6 μL | 82.9 μL | 165.9 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)