Aminopyrifen is a GWT-1 inhibitor. Aminopyrifen inhibits the inositol acylation of phosphatidylinositol, disrupting the maturation process of GPI-anchored proteins and the integrity of fungal cell walls. Aminopyrifen strongly inhibits germ tube elongation of Botrytis cinerea, delays spore germination, prevents appressorium formation, and blocks the infection of plant tissues by pathogenic fungi. Aminopyrifen is effective against field populations of eggplant gray mold and cucumber powdery mildew, and can be used for research on various plant fungal diseases such as gray mold and powdery mildew [1].
In Vitro, Aminopyrifen potently inhibits radial mycelial growth of most tested Ascomycetes and related anamorphic fungi (EC50: 0.0039-0.23 mg/L), shows variable activity against Basidiomycetes, and has no activity against the oomycete Pythium aphanidermatum[1]. Aminopyrifen (20 hr) does not inhibit Botrytis cinerea spore germination (EC50: >10 mg/L) but potently inhibits germ-tube elongation (EC50: 0.035 mg/L) and induces swollen germ-tube morphology[1].
References:
[1]. Hatamoto M, et al. Aminopyrifen, a novel 2-aminonicotinate fungicide with a unique effect and broad-spectrum activity against plant pathogenic fungi. J Pestic Sci. 2021;46(2):198-205.
In Vitro, Aminopyrifen potently inhibits radial mycelial growth of most tested Ascomycetes and related anamorphic fungi (EC50: 0.0039-0.23 mg/L), shows variable activity against Basidiomycetes, and has no activity against the oomycete Pythium aphanidermatum[1]. Aminopyrifen (20 hr) does not inhibit Botrytis cinerea spore germination (EC50: >10 mg/L) but potently inhibits germ-tube elongation (EC50: 0.035 mg/L) and induces swollen germ-tube morphology[1].
References:
[1]. Hatamoto M, et al. Aminopyrifen, a novel 2-aminonicotinate fungicide with a unique effect and broad-spectrum activity against plant pathogenic fungi. J Pestic Sci. 2021;46(2):198-205.