Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM[1].
Androgen receptor modulators 1 (Compounds 2f) induces sexual behavior at the minimal dose (0.5 mg/kg/day, qd, po). It could act as androgen agonist on the CNS[1].Androgen receptor modulators 1 shows good metabolic stabilities with little species difference between rat, dog, mouse, monkey and human[1].
[1]. Aikawa K, et al. Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate. Bioorg Med Chem. 2017 Jul 1;25(13):3330-3349.