AP 811 |
| カタログ番号GC50183 |
AP 811 は、選択的心房性ナトリウム利尿ペプチドクリアランス受容体 (APN-CR、NPR3) アンタゴニスト (Ki = 0.48 nM) です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 124833-45-0
Sample solution is provided at 25 µL, 10mM.
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High affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.
Veale et al (2000) The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg.Med.Chem.Lett. 10 1949 PMID:10987424 |William et al (2008) Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am.J.Physiol.Cell Physiol. 294 C1067 PMID:18272821 |Becker et al (2014) Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141 335 PMID:24353062
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