Apidaecin IA acetate is a basic peptide. Apidaecin IA acetate inhibits the enzymatic activity of DnaK. Apidaecin IA acetate induces bacterial cell death. Apidaecin IA acetate can be used in research related to peritonitis and bacterial infections [1] [2].
In Vitro, Apidaecin IA (100 ng/mL; 8 h) acetate inhibits DnaK activity and binds LPS, reducing bacterial survival by approximately 2 log10 at 8 h post-induction[1]. Apidaecin IA (0.02-200 μg/mL) acetate potently inhibits the growth of a variety of Gram-negative bacterial strains, with its MIC values ranging from 0.02 μg/mL to 0.2 μg/mL[2]. Apidaecin IA (100 μg/mL) acetate exhibits antibacterial activity against Escherichia coli NCTC 9001 cells. It inhibits the growth of the cells without causing immediate lysis, and does not interfere with the phospholipid bilayer[2].
References:
[1]. Krom RJ, et al. Engineered Phagemids for Nonlytic, Targeted Antibacterial Therapies. Nano letters. 2015 Jul 08;15(7):4808-13.
[2]. Casteels P, et al. Apidaecins: antibacterial peptides from honeybees. The EMBO journal. 1989 Aug;8(8):2387-91.
In Vitro, Apidaecin IA (100 ng/mL; 8 h) acetate inhibits DnaK activity and binds LPS, reducing bacterial survival by approximately 2 log10 at 8 h post-induction[1]. Apidaecin IA (0.02-200 μg/mL) acetate potently inhibits the growth of a variety of Gram-negative bacterial strains, with its MIC values ranging from 0.02 μg/mL to 0.2 μg/mL[2]. Apidaecin IA (100 μg/mL) acetate exhibits antibacterial activity against Escherichia coli NCTC 9001 cells. It inhibits the growth of the cells without causing immediate lysis, and does not interfere with the phospholipid bilayer[2].
References:
[1]. Krom RJ, et al. Engineered Phagemids for Nonlytic, Targeted Antibacterial Therapies. Nano letters. 2015 Jul 08;15(7):4808-13.
[2]. Casteels P, et al. Apidaecins: antibacterial peptides from honeybees. The EMBO journal. 1989 Aug;8(8):2387-91.