APJ receptor agonist 10 free base is an agonist of the APJ Receptor. APJ receptor agonist 10 free base can be used for research on pulmonary arterial hypertension [1].
In Vivo, APJ receptor agonist 10 free base (Compound I choline salt) (30 mg/kg; oral; single dose) demonstrates significantly higher oral bioavailability than Compound I free acid Form A in male Beagle dogs[1].
References:
[1]. Libo Chen, et al. Salts and solid forms of a compound having apj receptor activity. WO2024099382A1. 2023.
In Vivo, APJ receptor agonist 10 free base (Compound I choline salt) (30 mg/kg; oral; single dose) demonstrates significantly higher oral bioavailability than Compound I free acid Form A in male Beagle dogs[1].
References:
[1]. Libo Chen, et al. Salts and solid forms of a compound having apj receptor activity. WO2024099382A1. 2023.