ASO 556089 (with PS modification) sodium is the PS-modified version of ASO 556089. ASO 556089 sodium is a 16 nucleotide length gapmer (3-10-3) that targets the human and mouse long non-coding RNA MALAT1, with the sequence: 5’-GmCATTmCTAATAGmCAGmC-3’ [1].
In Vitro, ASO 556089 (with PS modification) sodium is the PS-modified version of ASO 556089.
References:
[1]. Nieskens TTG, et al. Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip. Arch Toxicol. 2021 Jun;95(6):2123-2136.
In Vitro, ASO 556089 (with PS modification) sodium is the PS-modified version of ASO 556089.
References:
[1]. Nieskens TTG, et al. Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip. Arch Toxicol. 2021 Jun;95(6):2123-2136.