Asperglaucide (Synonyms: Aurantiamide Acetate) |
カタログ番号GC46885
One-Click Copy Product Info
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多様な生物学的活性を持つアミド
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 56121-42-7
Sample solution is provided at 25 µL, 10mM.
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Asperglaucide is an amide originally isolated from P. aurantiacum that has diverse biological activities, including anti-inflammatory, antibacterial, antioxidant, and anticancer properties.1,2,3,4 Asperglaucide inhibits production of nitric oxide (NO), prostaglandin E2 , and IL-1β in LPS-stimulated BV-2 microglial cells (IC50s = 49.7, 51.5, and 40.4 µM, respectively).2 It is active against Gram-negative bacteria (MICs = 0.05-0.10 mg/ml) and has antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl and Trolox equivalent antioxidant capacity (TEAC) assays (EC50s = 9.51-78.81 µg/ml).3 Asperglaucide decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 µM and reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model.4
1.Banerji, A., and Ray, R.Aurantiamides: A new class of modified dipeptides from Piper aurantiacumPhytochemistry20(9)2217-2220(1981) 2.Yoon, C.S., Kim, D.C., Lee, D.S., et al.Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: Inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cellsInt. Immunopharmacol.23(2)568-574(2014) 3.Tamokou, J.D., Simo Mpetga, D.J., Keilah Lunga, P., et al.Antioxidant and antimicrobial activities of ethyl acetate extract, fractions and compounds from stem bark of Albizia adianthifolia (Mimosoideae)BMC Complement. Altern. Med.1299(2012) 4.Yang, Y., Zhang, L.H., Yang, B.X., et al.Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic fluxJ. Cell. Mol. Med.19(5)1055-1064(2015)
| Cas No. | 56121-42-7 | SDF | |
| 同義語 | Aurantiamide Acetate | ||
| Canonical SMILES | O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)COC(C)=O)=O)C3=CC=CC=C3 | ||
| Formula | C27H28N2O4 | M.Wt | 444.5 |
| 溶解度 | DMSO: soluble,Ethanol: soluble | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2497 mL | 11.2486 mL | 22.4972 mL |
| 5 mM | 449.9 μL | 2.2497 mL | 4.4994 mL |
| 10 mM | 225 μL | 1.1249 mL | 2.2497 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)