ATX-012 |
カタログ番号GC79710
One-Click Copy Product Info
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ATX-012 is an ionizable cationic lipid for the assembly of mRNA -delivering lipid nanoparticles (LNPs).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1777792-44-5
Sample solution is provided at 25 µL, 10mM.
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In Vivo, ATX-012 (intratracheal administration)-formulated LNPs deliver mRNA to mouse lung epithelial cells and drive protein expression throughout large and small airways[1]. ATX-012 (1 mg/kg; intranasal administration; once daily for two days)-based LNPs loaded with hCFTR mRNA restore functional chloride channel activity in CFTR knockout mice[1].
In Vitro, ATX-012 can form LNPs featuring high mRNA encapsulation efficiency (> 95%) and a small particle size ranging from 70 to 90 nm, and such LNPs achieve efficient mRNA delivery into lung epithelial cells in vitro and in vivo[1].
References:
[1]. Carlos G, et al. Lipid formulations containing nucleic acids and methods of treatment for cystic fibrosis. US20230159449A1. United States. 2022-11-03.
| Cas No. | 1777792-44-5 | SDF | |
| Formula | C42H78N2O5S | M.Wt | 723.14 |
| 溶解度 | Storage | Store at -20°C | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.3829 mL | 6.9143 mL | 13.8286 mL |
| 5 mM | 276.6 μL | 1.3829 mL | 2.7657 mL |
| 10 mM | 138.3 μL | 691.4 μL | 1.3829 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)