Azintuxizumab vedotin (Synonyms: ABBV-838) |
| カタログ番号GC74509 |
Azintuxizumab vedotin（ABBV-838）は、CD 2サブグループ1の独特なエピトープを標的とする抗体−薬物結合体（ADC）であり、CD 2サブグループ1は多発性骨髄腫細胞上で発現する細胞表面糖タンパク質である。
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Cas No.: 1826819-58-2
Sample solution is provided at 25 µL, 10mM.
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Azintuxizumab vedotin (ABBV-838) is an antibody–drug conjugate (ADC) targeting a unique epitope of CD2 subset 1, a cell-surface glycoprotein expressed on multiple myeloma cells.
Azintuxizumab vedotin (ABBV-838) is an ADC comprising a humanized recombinant immunoglobulin G1κ directed against a unique epitope of CD2 subset 1 (CS1, also known as SLAMF7) conjugated to the cytotoxic monometl auristatin E (MMAE) through a valine-citrulline linker[1].Azintuxizumab vedotin shows potent cytotoxic activity against cancer cells that expressed CS1[1].
Azintuxizumab vedotin (ABBV-838) shows single-agent antitumor activity in mouse models using human myeloma xenografts[1].
References:
[1]. Vij R, et al. First-in-Human Phase I Study of ABBV-838, an Antibody-Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma. Clin Cancer Res. 2020 May 15;26(10):2308-2317.
| Cas No. | 1826819-58-2 | SDF | |
| 同義語 | ABBV-838 | ||
| Formula | M.Wt | ||
| 溶解度 | Storage | ||
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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