BAPTA tetrapotassium |
| カタログ番号GC67211 |
BAPTA テトラカリウムは、カルシウムの選択的キレート剤です。カルシウム指示薬としての BAPTA は、マグネシウムとカルシウムに対して高い選択性を持っています。 BAPTA 四カリウムは、原形質膜の Ca2+- 透過性チャネルを介した細胞内ストアまたは流入からの Ca2+ 放出の影響を調査するための細胞内バッファーとして広く使用されています。 BAPTA 四カリウムは、Ca2+ キレート剤としての役割とは無関係に、ホスホリパーゼ C 活性を阻害することもできます。
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Cas No.: 73630-08-7
Sample solution is provided at 25 µL, 10mM.
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BAPTA tetrapotassium is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators[1][2][4].
BAPTA (0.3-30 μM; 1 h) can be used for the prevention of [Ca2+]-induced cell damage, but disturbe calcium signalling in isingle differentiated NH15-CA2 neuroblastoma and glioma hybrid cells[3].
BAPTA (0-10 mM) inhibits phospholipase C (PLC) activity in a dose-dependent manner, and is unrelated to Ca2+[2].
[1]. R Y Tsien, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980 May 27;19(11):2396-404.
[2]. Roger C Hardie, et al. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56.
[3]. M B Collatz, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium
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