BIX (Synonyms: BiP Inducer X) |
| カタログ番号GC50153 |
免疫グロブリン重鎖結合タンパク質 (BiP)/GRP78 の選択的インデューサーである BIX は、効果的な ER (小胞体) ストレス阻害剤です。
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Cas No.: 101714-41-4
Sample solution is provided at 25 µL, 10mM.
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BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo.
Inokuchi et al (2009) Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest.Ophthalmol.Vis.Sci. 50 334 PMID:18757512 |Oida et al (2008) Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 1208 217 PMID:18395193 |Kudo et al (2008) A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 15 364 PMID:18049481
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