BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2].
BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines[1].BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines[1].BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 µM both in GFP-transfected and in GFRD1-transfected cells[1].
[1]. Leo Jakman, Characterization of small-molecule GDNF mimics.
[2]. Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414.