Chitin |
カタログ番号GB57663
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Chitinは海洋甲殻類の殻から抽出された様々な糖質であり、自然界ではエビやカニなどに広く分布している。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1398-61-4
Sample solution is provided at 25 µL, 10mM.
Chitinは海洋甲殻類の殻から抽出された様々な糖質であり、自然界ではエビやカニなどに広く分布している[1]。Chitinはアミノ糖N-acetylglucosamineの線形多糖類であり、様々な無脊椎動物（例えばスポンジ、軟体動物、線虫、節足動物と菌類など）の細胞外マトリックスに存在する[2]。chitinの構造はセルロースに等しく、結晶ナノフィブリルまたはウィスカーを形成し、機能的にはタンパク質ケラチンと等しい[3]。ChitinはマクロファージTNFとIL-10製造のサイズ依存の調節剤である[4]。Chitinは体内で、TLR2とDectin-1受容体シグナル伝達経路を活性化し、抗炎症と組織修復反応を促進することで、M2マクロファージ分極を誘発できる[5]。Chitinは線維芽細胞を誘発し、インターロイキン-8（IL-8）を放出し、IL-8は、線維芽細胞と血管内皮細胞の遊離と増殖に関与している[6]。
References:
[1] Arbia W, Arbia L, Adour L, et al. Chitin extraction from crustacean shells using biological methods–a review[J]. Food Technology and Biotechnology, 2013, 51(1): 12-25.
[2] Moussian B. Chitin: Structure, chemistry and biology[J]. Targeting chitin-containing organisms, 2019: 5-18.
[3] Ifuku S, Saimoto H. Chitin nanofibers: preparations, modifications, and applications[J]. Nanoscale, 2012, 4(11): 3308-3318.
[4] Da Silva C A, Chalouni C, Williams A, et al. Chitin is a size-dependent regulator of macrophage TNF and IL-10 production[J]. The Journal of immunology, 2009, 182(6): 3573-3582.
[5] Lee C G, Da Silva C A, Dela Cruz C S, et al. Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury[J]. Annual review of physiology, 2011, 73(1): 479-501.
[6] Okamoto Y, Watanabe M, Miyatake K, et al. Effects of chitin/chitosan and their oligomers/monomers on migrations of fibroblasts and vascular endothelium[J]. Biomaterials, 2002, 23(9): 1975-1979.
| Cas No. | 1398-61-4 | SDF | |
| Formula | (C8H13NO5 )n | M.Wt | |
| 溶解度 | Storage | Store at RT | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Appearance: A solid
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)