Conglobatin |
| カタログ番号GC18832 |
コングロバチンは、元々Sから単離された二量体のマクロライドジラクトンです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72263-05-9
Sample solution is provided at 25 µL, 10mM.
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Conglobatin is a dimeric macrolide dilactone originally isolated from S. conglobatus. It disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 breast cancer cells. It also inhibits cell proliferation in HER2+ breast cancer cell lines (IC50s = 12.9-61.5 uM, respectively) and decreases the number of invasive cells in vitro. When combined with lapatinib , tumor growth of SK-BR-3 mouse xenografts was reduced to a greater degree than with conglobatin alone. Conglobatin has various anticancer effects in esophageal squamous cell carcinoma (ESCC) models as well, including an inhibition of cell proliferation in KYSE510 cells (IC50 = 9.31 uM). It also inhibits β1 integrin activation leading to a loss of cellular adhesion.
Review for Conglobatin
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
Review for Conglobatin
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