CTX-1211 is a peptide agonist of melanocortin receptors.1 It increases intracellular cAMP levels in cells expressing melanocortin receptor 1 (MC1R), MC3R, or MC4R (EC50s = 6.2, 3.9, and 2.7, nM, respectively). CTX-1211 (1 mg/kg) sensitizes male and female mice to reductions in food intake and body weight induced by liraglutide but with a lower effect on food intake in female mice.2
References:
[1]. Sharma, S.Peptide Compositions(2014).
[2]. Dahir, N.S., Gui, Y., Wu, Y., et al.Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in miceJ. Clin. Invest.134(14)e178250(2024).