CU-115 |
| カタログ番号GC47127 |
CU-115 は強力な TLR8 アンタゴニスト (IC50=1.04 μM) であり、TLR7 よりも TLR8 に選択的です (IC50=>50 μM)。
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Cas No.: 2471982-20-2
Sample solution is provided at 25 µL, 10mM.
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CU-115 is a toll-like receptor 8 (TLR8) antagonist (IC50 = 1.04 µM).1 It is selective for TLR8 over TLR7 (IC50 = >50 µM). CU-115 inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD in a luciferase reporter assay when used at concentrations of 5 and 20 µM. It decreases TNF-α and IL-1β production induced by R-848 in THP-1 cells when used at a concentration of 5 µM.
1.Padilla-Salinas, R., Anderson, R., Sakaniwa, K., et al.Discovery of novel small molecule dual inhibitors targeting toll-like receptors 7 and 8J. Med. Chem.62(22)10221-10244(2019)
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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