Dihydrotetrabenazine (Synonyms: DTBZ, trans-(2,3)-Dihydro Tetrabenazine) |
| カタログ番号GC40143 |
ジヒドロテトラベナジンは、肝臓カルボニル還元酵素によって生成される膜包装型単胺類似物質輸送体2（VMAT2）阻害剤であるテトラベナジンの活性代謝産物です。
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Cas No.: 3466-75-9
Sample solution is provided at 25 µL, 10mM.
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Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively). It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (Kds = 2.9, 2.5, and 2.8 nM, respectively). Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.
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