DYn-2 (Synonyms: Click Tag DYn2) |
| カタログ番号GC43581 |
穏やかな酸化作用により、タンパク質中のシステイン残基の硫黄水素基がシステイン-スルフェニル酸誘導体（Cys-SOH）に変換されることがあります。
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Cas No.: 1354630-46-8
Sample solution is provided at 25 µL, 10mM.
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Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH). Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells. DYn-2 consists of 1,3-cyclohexanedione coupled to an alkyne moiety by a 3-carbon spacer. The cyclohexanedione group selectively reacts with protein sulfenic acid modifications. The alkyne group of DYn-2 can then be detected using azide-bearing tags by standard click chemistry. This approach offers superior sensitivity relative to using azide-modified probes with alkynyl detection tags.
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