Tavilermide (MIM-D3) (Synonyms: MIM-D3) |
| カタログ番号GC31676 |
タビレルミド (MIM-D3) は、TrkA の選択的部分アゴニスト、または神経成長因子 (NGF) ミメティックです。
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Cas No.: 263251-78-1
Sample solution is provided at 25 µL, 10mM.
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Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.
Tavilermide (MIM-D3) is a tyrosine kinase TrkA receptor agonist, which can be used to treat dry eye.Tavilermide is a proteolytically stable, cyclic peptidomimetic that has been shown to be a partial TrkA receptor agonist. Tavilermide demonstrates activities similar to NGF (but does not bind to the p75NTR receptor) and can potentiate the effects of suboptimal concentrations of NGF[1].
[1]. Meerovitch K, et al. Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye. Clin Ophthalmol. 2013;7:1275-85.
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