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Eflornithine (DFMO)

カタログ番号: GC30283

エフロルニチン (DFMO) は、酵素オルニチン デカルボキシラーゼの特異的で不可逆的な阻害剤です。

Eflornithine (DFMO) 化学構造

サイズ 価格 在庫数 個数
10mg
$47.00
在庫あり
50mg
$88.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

品質管理 & SDS

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Protocol

Animal experiment:

Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (∼50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3].

References:

[1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.
[2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202.
[3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501.
[4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312.

背景

Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4].

[1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312.

化学的性質

Cas No. 70052-12-9 SDF いいえ
同義語 該当無し
Chemical Name 該当無し
Canonical SMILES NC(CCCN)(C(F)F)C(O)=O
Formula C6H12F2N2O2 M.Wt 182.17
溶解度 Soluble in H2O Storage Store at -20°C
一般的なヒント より高い溶解度を得るためには、37 度でチューブを温めてください。それを超音波風呂で揺らして泡立てます。在庫ソリューションは -20度以下で数カ月保存できます。
出荷条件 評価サンプルソリューション: zip with blue ice
その他すべての利用可能サイズ: ship with RT, or blue ice

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Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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