ER-076349 |
カタログ番号GC74126
One-Click Copy Product Info
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ER-076349はチューブリン重合の阻害剤であり、g2-m細胞周期停止を誘導し、有糸分裂スピールを攪乱する。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 253128-15-3
Sample solution is provided at 25 µL, 10mM.
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ER-076349 is an inhibitor of tubulin polymerization, induces G2-M cell cycle arrest, and disrupts mitotic spindles. ER-076349 inhibits cancer cell growth, and inhibits tumor growth in several human tumor xenografts. ER-076349 is an analog of Halichondrin B.
ER-076349 inhibits human cancer cell growth with IC50s of 0.59 nM (MDA-MB-435), 2.4 nM (COLO 205), 7.3 nM (DLD-1), 3.6 nM (DU 145), 1.8 nM (LNCaP), 3.2 nM (LOX ), 2.6 nM (HL-60), 4.0 nM (U937) respectively[1].
References:
[1]. Towle MJ, et al. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res. 2001 Feb 1;61(3):1013-21.
| Cas No. | 253128-15-3 | SDF | |
| Formula | C40H58O12 | M.Wt | 730.88 |
| 溶解度 | Storage | -80°C, protect from light, stored under nitrogen | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3682 mL | 6.8411 mL | 13.6821 mL |
| 5 mM | 273.6 μL | 1.3682 mL | 2.7364 mL |
| 10 mM | 136.8 μL | 684.1 μL | 1.3682 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)