Flucofuron exhibits high efficacy against trophozoites of both N. fowleri strains (ATCC 30808: IC50 = 2.58 μM and ATCC 30215: IC50 = 2.47 μM), being even active against the resistant cyst stage ( IC50 = 0.88 μM). Flucofuron can induce cell apoptosis. Flucofuron can be used for the researches of infection and inflammation, such as Primary amoebic meningoencephalitis (PAM) [1].
References:
[1]. Chao-Pellicer J, et al. Flucofuron as a Promising Therapeutic Agent against Brain-Eating Amoeba. ACS Infect Dis. 2024 Jun 14;10(6):2063-2073.
References:
[1]. Chao-Pellicer J, et al. Flucofuron as a Promising Therapeutic Agent against Brain-Eating Amoeba. ACS Infect Dis. 2024 Jun 14;10(6):2063-2073.
















