(S)-Mapracorat (Synonyms: (S)-ZK-245186; (S)-BOL-303242X) |
| カタログ番号GC35002 |
(S)-マプラコラートは、選択的で活性の低いグルココルチコイド受容体アゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 887375-15-7
Sample solution is provided at 25 µL, 10mM.
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(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.
Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.
[1]. BÄumer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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