Iristectorin B |
カタログ番号GC36331
One-Click Copy Product Info
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Iristectorin BはIris tectorumに由来する天然のイソフラボンであり、抗癌作用を持つ。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 94396-09-5
Sample solution is provided at 25 µL, 10mM.
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Iristectorin BはIris tectorumに由来する天然のイソフラボンであり、抗癌作用を持つ[1]。Iristectorin Bは、リポ多糖（LPS）によるNOの産生を阻害することで、抗炎症活性を発揮できる[2]。Iristectorin Bは内部標準物質として広く使われ、関連する化合物の抽出と分離のためのイオン液体超音波併用抽出法を開発する[3]。
In vitro（体外）実験で、Iristectorin B（25µM）で24時間処理したところ、グルコース・酸素の欠乏/再酸素化（OGD/R）処理後、PC12細胞の生存率が著しく向上し、細胞アポトーシスが減少し、TFR1、HMOX1とSLC3A2の発現が著しく低下した[4]。
References:
[1] Ruan L J, Yan B X, Wu Y Q, et al. Integrated Chemometric and Spectrum-effect analysis discriminates Belamcanda chinensis and Iris tectorum in treating A549 lung Cancer cells[J]. Journal of Chromatography B, 2025: 124875.
[2] Gao B, Ma Y, Zhang L, et al. Identification and characterization of the chemical components of Iris tectorum Maxim. and evaluation of their nitric oxide inhibitory activity[J]. Rapid communications in mass spectrometry, 2021, 35(1): e8959.
[3] Sun Y, Li W, Wang J. Ionic liquid based ultrasonic assisted extraction of isoflavones from Iris tectorum Maxim and subsequently separation and purification by high-speed counter-current chromatography[J]. Journal of Chromatography B, 2011, 879(13-14): 975-980.
[4] Zheng M, Zhou M, Lu T, et al. TMT and PRM Based Quantitative Proteomics to Explore the Protective Role and Mechanism of Iristectorin B in Stroke[J]. International Journal of Molecular Sciences, 2023, 24(20): 15195.
| 細胞実験[1]: | |||
細胞株 | PC12細胞 | ||
準備方法 | 37℃、5% CO2の存在下で、10%のウシ胎児血清（FBS）と1% のペニシリン/ストレプトマイシンを添加した高グルコースDMEM培地でPC12細胞を培養した。10mM Na2S2O4を含有する100μlの無糖EBSS溶液を添加し、2時間インキュベートした。再酸素化のために、細胞を正常な培地に替え、引き続き24時間培養し、虚血脳損傷を模倣したOGD/R損傷モデルを構築した。OGD/R処理後、6.25µM、12.5µMと25µMのIristectorin Bを含有する正常培地で24時間添加、培養した。細胞の生存率を分析した。 | ||
反応条件 | 6.25µM、12.5µMと25µM；24時間 | ||
アプリケーション | Iristectorin Bの処理は、OGD/R損傷後のPC12細胞の生存率を増強させた。 | ||
| Cas No. | 94396-09-5 | SDF | |
| Canonical SMILES | O=C1C(C2=CC=C(O)C(OC)=C2)=COC3=CC(O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C(OC)C(O)=C13 | ||
| Formula | C23H24O12 | M.Wt | 492.43 |
| 溶解度 | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0307 mL | 10.1537 mL | 20.3075 mL |
| 5 mM | 406.1 μL | 2.0307 mL | 4.0615 mL |
| 10 mM | 203.1 μL | 1.0154 mL | 2.0307 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)