GRL093-22 is a potent and selective G protein-coupled receptor kinase ( GRK ) inhibitor, with IC50 s of 60 and 40 nM for GRK5 and GRK6, respectively. GRL093-22 has the potential for the research of heart failure and multiple myeloma [1].
References:
[1]. Ghosh AK, et, el. Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors. Eur J Med Chem. 2025 Jan 15:282:117024.
References:
[1]. Ghosh AK, et, el. Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors. Eur J Med Chem. 2025 Jan 15:282:117024.