κ-Carrageenan |
カタログ番号GC20004
One-Click Copy Product Info
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κ-カラギーナンは、主に赤色海藻に存在する天然高分子です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 11114-20-8
Sample solution is provided at 25 µL, 10mM.
κ-Carrageenan is the sulfated form of D-galactan obtained from the red algae, which is commonly used to prepare edible films [1]. In aqueous solution at elevated temperatures, κ-Carrageenan dissolves as random coils, whereas at lower temperatures, κ-Carrageenan forms a 3D polymeric network through sulphate groups and the 3,6-anhydro-β-D-galactopyranosyl ring[2]. κ-Carrageenan has been widely used as an emulsifier and stabilizer in beverage preservation, and to prevent fat droplets from coagulating during storage[3]. κ-Carrageenan has been widely used as a carrier to facilitate the targeted delivery of curcumin to cancer cells[4].
In vitro, κ-Carrageenan treatment (10µg/ml) for 24h significantly inhibited the viability of differentiated Caco-2 cells, and induced apoptosis and necrosis of the cells[5].
In vivo, κ-Carrageenan treatment via oral administration at a dose of 8.3mg/kg for 24h exacerbated the intestinal inflammation induced by oxazolone in BALB/c mice, resulting in a significant decrease in body weight and a lower survival rate of the mice[6]. A single intraperitoneal injection of a 20mg/kg dose of κ-Carrageenan for 2 days significantly induced thrombosis in the tail of mice[7]. Feeding a high-fat diet containing 0.2% (w/w) κ-Carrageenan for 8 weeks significantly reduced high-fat diet-induced body weight gain, lowered blood lipids and systemic inflammation, and improved intestinal barrier dysfunction in mice [8].
References:
[1] Paula G A, Benevides N M B, Cunha A P, et al. Development and characterization of edible films from mixtures of κ-carrageenan, ι-carrageenan, and alginate[J]. Food hydrocolloids, 2015, 47: 140-145.
[2] Russo Spena S, Grizzuti N. κ-Carrageenan and Its Synergistic Blends: Next-Generation Food Gels[J]. Gels, 2025, 11(12): 976.
[3] Xu H, Gao Z, Huang M, et al. Static stability of partially crystalline emulsions stabilized by milk proteins: Effects of κ-carrageenan, λ-carrageenan, ι-carrageenan, and their blends[J]. Food Hydrocolloids, 2024, 147: 109387.
[4] Nabipour H, Aliakbari F, Volkening K, et al. Novel metal-organic framework coated with chitosan-κ-carrageenan as a platform for curcumin delivery to cancer cells[J]. International Journal of Biological Macromolecules, 2025, 301: 140027.
[5] Jiang H Y, Wang F, Chen H A I M I N, et al. κ-carrageenan induces the disruption of intestinal epithelial Caco-2 monolayers by promoting the interaction between intestinal epithelial cells and immune cells[J]. Molecular Medicine Reports, 2013, 8(6): 1635-1642.
[6] Wu W, Wang F, Gao X, et al. Synergistic effect of κ-carrageenan on oxazolone-induced inflammation in BALB/c mice[J]. BMC gastroenterology, 2016, 16(1): 41.
[7] Zhou H, Zhu J, Wan H, et al. The combination of danhong injection plus tissue plasminogen activator ameliorates mouse tail thrombosis-induced by κ-carrageenan[J]. Phytomedicine, 2022, 104: 154320.
[8] Wang Q, Zhang L, He Y, et al. Effect of κ-carrageenan on glucolipid metabolism and gut microbiota in high-fat diet-fed mice[J]. Journal of Functional Foods, 2021, 86: 104707.
| Cell experiment [1]: | |
Cell lines | Caco-2 cells |
Preparation Method | Caco-2 cells at passages 30-60 were cultured in Dulbecco’s modified Eagle’s medium/Nutrient Mix F12 supplemented with 10% fetal bovine serum, 100U/ml penicillin, and 100μg/ml streptomycin at 37°C with 5% CO2 and 95% saturated atmospheric humidity. Cells were seeded into 24-well microplates at a density of 3×105 cells/well for 24h. Various concentrations of κ-Carrageenan (0, 1, 2, 5, and 10µM) were added to each well. At the end of the incubation period (24h at 37°C), cell viability was analyzed. |
Reaction Conditions | 0, 1, 2, 5, and 10µM; 24h |
Applications | κ-Carrageenan treatment significantly reduced the cell viability of Caco-2 cells in a dose-dependent manner. |
| Animal experiment [2]: | |
Animal models | C57BL/6J mice |
Preparation Method | C57BL/6J mice, 7 weeks old, were maintained under a 12-h light and 12-h dark cycle at a temperature of 25°C and humidity of 50%±10%, free with water and diet. After one week of adaptation, all mice were randomly divided into 3 groups (n=8), including a normal control group (ND):10% low-fat control feed; high-fat control group (HFD):60% high-fat model feed; κ-Carrageenan group: 60% high-fat model feed added 0.2% (w/w) κ-Carrageenan. The intervention time was 8 weeks. The weight and food intake of mice were recorded every week. |
Dosage form | 0.2% (w/w) in 60% high-fat feed; every day for 8 weeks; p.o. |
Applications | κ-Carrageenan significantly reduced the weight gain caused by high-fat diet without affecting the food intake of mice. |
References: | |
| Cas No. | 11114-20-8 | SDF | |
| Formula | M.Wt | ||
| 溶解度 | Water : 8.33 mg/mL (ultrasonic and warming and heat to 80°C); DMSO : 8.33 mg/mL (ultrasonic and warming and heat to 80°C) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)