Kigamicin C |
| カタログ番号GC44003 |
キガマイシンは、栄養欠乏条件下でのみ膵臓がんPANC-1細胞を選択的に殺す天然の抗腫瘍抗生物質です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 680571-51-1
Sample solution is provided at 25 µL, 10mM.
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Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions. They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media. A related compound, kigamicin D, is active in vivo, suppressing the tumor growth of several pancreatic cancer cell lines in nude mice. It blocks the activation of Akt induced in PANC-1 cells placed in nutrient-deprived media. Kigamicin can also induce necrosis in human myeloma cells, but not normal lymphocytes, maintained in nutrient-rich media (CC50 = 100 nM).
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