LIBX-A401 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4; IC50 = 0.38 ?M).1 It is selective for ACSL4 over ACSL3 (IC50 = >50 ?M) and peroxisome proliferator-activated receptor γ (PPARγ; IC50 = >10 ?M).
References:
[1]. Dorooee, D.M., Ravez, S., Vertommen, D., et al.LIBX-A401: A novel selective inhibitor of acyl-coa synthetase long chain family member 4 (ACSL4) and its binding modeChemRxiv(2024).