GLPBio

MDOLL-0286

Catalog No.: GC79105Purity:>99.50%
COASDSData Sheet
MDOLL-0286 is a selective Poly(ADP-ribose) Glycohydrolase (PARG) ( ARH3 ) inhibitor with an IC50 of 2.3μM.

製品は研究用途にのみ使用できます。人体には使用できません。患者への販売は行っておりません。

MDOLL-0286
5mgIn Stock
$261.00
1
10mgIn Stock
$418.00
1
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引用文献 (Citations)

現在、この製品の引用文献はありません。以下はGlpBio製品を引用した代表的な文献です。
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

製品説明 (Description)

MDOLL-0286 is a selective Poly(ADP-ribose) Glycohydrolase (PARG) ( ARH3 ) inhibitor with an IC50 of 2.3μM. MDOLL-0286 can inhibit ARH3’s poly-ADP-ribose hydrolytic activity on cellular substrates. MDOLL-0286 can inhibit DNA damage response. MDOLL-0286 can be used for the research of cancer [1].

References:
[1]. Parviainen TAO, et al. Discovery and Structural Optimization of 2-Hydrazinopyrimidin-4-one Analogs Inhibiting Human ADP-Ribosylhydrolase ARH3. ACS Chem Biol. 2025 Sep 15.

製品資料 (Product Documents)

Purity:>99.50%Appearance:A solid
COASDSData Sheet

化学的性質 (Chemical Properties)

分子式
C16H21N5O
分子量
299.37
溶解性
DMSO: 1 mg/mL (3.34 mM; ultrasonic and warming and heat to 60°C)
保存条件
Store at -20°C
配送条件
評価用サンプルは保冷剤とともに発送します。その他の容量は室温で発送し、ご要望に応じて保冷剤を同梱します。

計算ツール (Calculators)モル濃度 / 希釈 / 分子量 / 単位変換 / in vivo製剤 / 溶解度

g/mol

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