ML401 |
| カタログ番号GC38820 |
強力な化学プローブである ML401 は、1.03 nM の IC50 で EBI2 (GPR183 としても知られる) に選択的に拮抗します。
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Cas No.: 1597489-14-9
Sample solution is provided at 25 µL, 10mM.
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ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].
ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM)[1].
ML401 shows very good stability in both human plasma and mouse plasma[1].
[1]. Ardecky R, et al. Functional Antagonists of EBI-2. Probe Reports from the NIH Molecular Libraries Program [Internet].
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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