Nesiritide is a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide .1 It increases ex vivo vasorelaxation induced by the calcium ionophore A23187 in porcine hearts isolated from a model of acute coronary occlusion when administered as a 2 µg/kg bolus dose followed by 0.01 µg/kg per minute infusion.2 Formulations containing nesiritide have previously been used in the treatment of congestive heart failure.
1.Hobbs, R.E., and Mills, R.M.Therapeutic potential of nesiritide (recombinant b-type natriuretic peptide) in the treatment of heart failureExpert Opin. Investig. Drugs8(7)1063-1072(1999) 2.Lazar, H.L., Bao, Y., Siwik, D., et al.Nesiritide enhances myocardial protection during the revascularization of acutely ischemic myocardiumJ. Card. Surg.24(5)600-605(2009)