Penduletin is a flavone, that can be isolated from Brickelia pendula and Vitex negundo. Penduletin shows anticancer activity. Penduletin induces apoptosis in the cancer cells through ROS generation.
Penduletin (0-100 µg/mL, 48 h) shows antiproliferative activity against HepG2 and MCF-7 cell lines, with IC50 values of 25.8, and 6.4 µM, respectively[1].Penduletin exhibits an enhanced ability to induce the cleavage of procaspase‐3 in HepG2 and both procaspase‐3 and procaspase‐8 in MCF-7 cells line[1].
References:
[1]. Flores S E, et al.The structure of pendulin and penduletin: a new flavonol glucoside isolated from brickelia pendula[J].Tetrahedron, 1958, 2(3-4):308-315. [2]. Vo GV, et al. In silico and in vitro studies on the anti-cancer activity of artemetin, vitexicarpin and penduletin compounds from Vitex negundo. Saudi Pharm J. 2022 Sep;30(9):1301-1314.