GLPBio

PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt)

Catalog No.: GC92090Purity:>99.00%Synonyms: DPPI-4,5-P2-d62; Phosphatidylinositol-4,5-diphosphate C16-d62; PI(4,5)P2 (16:0/16:0)-d62; PIP2[4',5'](16:0/16:0)-d62
COASDSData Sheet
PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt)GCまたはLC質量分析によるPtdIns-4,5-P 2 1,2-ジパルミトイドナトリウム塩の定量のための内部標準として使用することを目的としている。

製品は研究用途にのみ使用できます。人体には使用できません。患者への販売は行っておりません。

PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt)
25 µgIn Stock
$130.00
1
50 µgIn Stock
$246.00
1
100 µgIn Stock
$462.00
1
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引用文献 (Citations)

現在、この製品の引用文献はありません。以下はGlpBio製品を引用した代表的な文献です。
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

製品説明 (Description)

PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62 (sodium salt) is intended for use as an internal standard for the quantification of PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt) by GC- or LC-mass spectrometry. The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-4,5-P2-(1,2-dipalmitoyl)-d62 is a synthetic analog of natural PtdIns containing deuterated C16:0 fatty acids at the sn-1 and sn-2 positions. This synthetic standard features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of phosphatidylinositol 4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

References:
[1]. Exton, J.H.Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteinsAnnu. Rev. Pharmacol. Toxicol.36481-509(1996).
[2]. Majerus, P.W.Inositol phosphate biochemistryAnnu. Rev. Biochem.61225-250(1992).

製品資料 (Product Documents)

Purity:>99.00%Appearance:A solid
COASDSData Sheet

化学的性質 (Chemical Properties)

同義語
DPPI-4,5-P2-d62; Phosphatidylinositol-4,5-diphosphate C16-d62; PI(4,5)P2 (16:0/16:0)-d62; PIP2[4',5'](16:0/16:0)-d62
化学名
1-(1,2-dihexadecanoyl(2,2’,3,3’,4,4’,5,5’,6,6’,7,7’,8,8’,9,9’,10,10’,11,11’,12,12’,13,13’,14,14’,15,16,16,16-d31)phosphatidyl)inositol-4,5-bisphosphate, trisodium salt
SMILES
O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H](O)[C@H]1OP([O-])(OCC(COC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O.[Na+].[Na+].[Na+]
分子式
C41H16D62O19P3 ? 3Na
分子量
1099.3
保存条件
-20°C
一般的な注意事項
製品の溶解性データに基づいて適切な溶媒を選択してください。調製後は、凍結融解の繰り返しを避けるため、ストック溶液を小分けしてください。
ストック溶液は、-80°Cで保存する場合は6か月以内、-20°Cで保存する場合は1か月以内に使用してください。
溶解性を高めるには、チューブを37°Cに温め、適切な時間超音波処理してください。
配送条件
評価用サンプルは保冷剤とともに発送します。その他の容量は室温で発送し、ご要望に応じて保冷剤を同梱します。

計算ツール (Calculators)モル濃度 / 希釈 / 分子量 / 単位変換 / in vivo製剤 / 溶解度

g/mol

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