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GPR139

GPR139 (G protein-coupled receptor 139) is a protein that in humans is encoded by the GPR139 gene. GPR139 is an orphan G-protein–coupled receptor expressed in the central nervous system.

The expression pattern of GPR139 has primarily been studied on the mRNA level and showed expression mainly in the central nervous system.

GPR139 is an orphan receptor identified from bioinformatics analysis of the human genome. GPR139 is thus a potential target for the treatment of Parkinson’s disease, obesity, eating disorders, and/or diabetes.

The GPR139 is expressed specifically in the brain in areas of relevance for motor control. GPR139 function and signal transduction pathways are elusive, and results in the literature are even contradictory. GPR139 agonists dose-dependently protect primary dopaminergic (DA) neurons against MPP+ toxicity.

対象は  GPR139

製品は  GPR139

  1. Cat.No. 商品名 インフォメーション
  2. GC19209 JNJ-63533054 JNJ-63533054 は、ヒト GPR139 (hGPR139) に対して 16 nM の EC50 を持つ強力で選択的な経口活性 GPR139 アゴニストです。 JNJ-63533054  Chemical Structure
  3. GC66431 NCRW0005-F05 NCRW0005-F05 は、IC50 値が 0.21 μ の強力な GPR139 アゴニストです。 NCRW0005-F05 は、糖尿病、肥満、パーキンソン病の研究に使用できます。 NCRW0005-F05  Chemical Structure

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