SBI-477 |
| カタログ番号GC39147 |
SBI-477 は、転写因子 MondoA を不活性化することによってインスリンシグナル伝達を刺激する化学プローブであり、インスリン経路サプレッサーであるチオレドキシン相互作用タンパク質 (TXNIP) およびアレスチンドメイン含有 4 (ARRDC4) の発現を低下させます。
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Cas No.: 781628-99-7
Sample solution is provided at 25 µL, 10mM.
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SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1].
[1]. Ahn B, et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126(9):3567-79.
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