SH-0029 is a SOX10 inhibitor with activity against melanoma. SH-0029 disrupts DNA-binding and transcriptional activity in melanoma. SH-0029 can be used for the research of melanoma [1].
In Vitro, SH-0029 potently inhibits SOX10 function in melanoma cells by disrupting its DNA-binding and transcriptional activity[1].
References:
[1]. Lin Z, et al. Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies. Cancer biology & medicine. 2025 Jul 24;22(7):726-46.
In Vitro, SH-0029 potently inhibits SOX10 function in melanoma cells by disrupting its DNA-binding and transcriptional activity[1].
References:
[1]. Lin Z, et al. Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies. Cancer biology & medicine. 2025 Jul 24;22(7):726-46.