SPI 112 |
| カタログ番号GC46011 |
SPI 112 は、SHP2、プロテイン チロシン ホスファターゼ (PTP)、および PTP1B に対してそれぞれ 1 μM、18.3 μM、および 14.5 μM の IC50 を持つ、強力で選択的かつ競合的な SHP2 (PTPN11) 阻害剤です。
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Cas No.: 1051387-90-6
Sample solution is provided at 25 µL, 10mM.
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SPI 112 is cell-impermeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2) in cell-free assays (IC50 = 1 μM).1 It selectively inhibits SHP-2 over SHP-1 and protein tyrosine phosphatase 1B (PTP1B; IC50s = 18.3 and 14.5 μM, respectively).
|1. Lawrence, H.R., Pireddu, R., Chen, L., et al. Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J. Med. Chem. 51(16), 4548-4956 (2008).
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