STK683963 is a strong activator of cellular ATG4B activity. STK683963 can act as a mediator of redox-regulation of ATG4B in cells. STK683963 can be used for the research of cancer.
STK683963 (0-50 μM) strongly up-regulates the luciferase release reporter in a dosedependent manner after 24 h[1]. STK683963 strongly activates luciferase release, which was completely blocked in the presence of NAC[1].
References:
[1]. Niccolo Pengo, et al. Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells. Front Cell Dev Biol. 2018 Nov 1;6:148.