UCB-6876 is a TNFα inhibitor and binds to asymmetrical crystal form of the TNF trimer (KD = 22 μM).
References:
[1]. Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021 Nov 23;13(1):90.
[2]. O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10(1):5795.