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JT71

Catalog No.GC78829 Copy One-Click Copy Product Info

JT71 is an inhibitor of the transcriptional activator MrkH of type III fimbriae in Klebsiella pneumoniae.

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JT71 Chemical Structure

Cas No.: 380887-90-1

Size Price Stock Qty
5mg
$72.00
In stock
10mg
$115.00
In stock
25mg
$207.00
In stock
50mg
$331.00
In stock
100mg
$530.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of JT71

JT71 is an inhibitor of the transcriptional activator MrkH of type III fimbriae in Klebsiella pneumoniae. JT71 reduces the activity of the mrkA promoter in Klebsiella pneumoniae, effectively inhibiting the formation of biofilms by Klebsiella pneumoniae, while not affecting the cell's viability. JT71 can be used for research on Klebsiella pneumoniae infections [1].

References:
[1]. Wilksch JJ, et al. Chemical inhibition of MrkH-dependent activation of type 3 fimbriae synthesis and biofilm formation by Klebsiella pneumoniae. NPJ Biofilms Microbiomes. 2025 Nov 20;11(1):212.

Chemical Properties of JT71

Cas No. 380887-90-1 SDF
Formula C18H18N2O2S M.Wt 326.41
Solubility DMSO: 4.17 mg/mL (12.78 mM; Need ultrasonic) Storage Store at -20°C
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of JT71

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.0636 mL 15.3182 mL 30.6363 mL
5 mM 612.7 μL 3.0636 mL 6.1273 mL
10 mM 306.4 μL 1.5318 mL 3.0636 mL
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In vivo Formulation Calculator (Clear solution) of JT71

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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