GLPBio

JWH 018 8-quinolinyl carboxamide

Catalog No.: GC41259Purity:>98.00%
JWH 018 is a synthetic cannabinoid (CB) that potently activates both the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).

Products are for research use only. Not for human use. We do not sell to patients.


JWH 018 8-quinolinyl carboxamide
Cas No.: 1400742-39-3
1mgIn Stock
$125.00
1
5mgIn Stock
$548.00
1
10mgIn Stock
$973.00
1

Citations

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  • Nature cover
    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

JWH 018 is a synthetic cannabinoid (CB) that potently activates both the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively). This cannabimimetic compound has frequently been found in herbal blends. Structurally, JWH 018 is an alkylindole joined to a naphthyl group by methanone. JWH 018 8-quinolinyl carboxamide is a structural analog of JWH 018 in which the naphthalenyl methanone portion has been replaced by 8-quinolinyl carboxamide. The physiological and toxicological properties of this compound have not been investigated. This product is intended for research and forensic applications.

Product Documents

Purity:>98.00%Appearance:A solid

Chemical Properties

CAS No.
1400742-39-3
SMILES
O=C(NC1=C(N=CC=C2)C2=CC=C1)C3=CN(CCCCC)C4=C3C=CC=C4
Molecular Formula
C23H23N3O
Molecular Weight
357.5
Solubility
DMF: 16.6 mg/ml,DMF:PBS(pH7.2) (1:2): 0.33 mg/ml,DMSO: 0.16 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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