JY-2
Catalog No.: GD96632Purity:>99.75%
JY-2 is a moderately selective FoxO1 inhibitor with IC50 of 22μM, JY-2 has moderate inhibitory effect on FoxO3a and FoxO4 too.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 339103-05-8
5mgIn Stock
$54.00
1
10mgIn Stock
$90.00
1
25mgIn Stock
$180.00
1
50mgIn Stock
$270.00
1
100mgIn Stock
$405.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 5mg | $54.00 | In Stock | 1 | |
| 10mg | $90.00 | In Stock | 1 | |
| 25mg | $180.00 | In Stock | 1 | |
| 50mg | $270.00 | In Stock | 1 | |
| 100mg | $405.00 | In Stock | 1 |
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com
Citations
2 publicationsPublications from researchers using this productDescription
JY-2 is a moderately selective FoxO1 inhibitor with IC50 of 22μM, JY-2 has moderate inhibitory effect on FoxO3a and FoxO4 too [1].
JY-2(0.5mM; 24h) reduced the palmitic acid (PA)-stimulated mRNA expression of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), two key enzymes involved in gluconeogenesis in HepG2 cells[1]. FoxO3 inhibitor JY-2 can antagonize cell iron death induced by Genistein via FoxO3/SLC7A11/GPX4 signaling pathway[2].
JY-2(50, 100, 200mg/kg; p.o; 3 times) improved glucose tolerance, in parallel with a reduced mRNA expression of gluconeogenic genes in high fat-diet induced obese and diabetic (DIO) mice models[1].
References:
[1]. Choi HE, Kim Y, et,al. Novel FoxO1 inhibitor, JY-2, ameliorates palmitic acid-induced lipotoxicity and gluconeogenesis in a murine model. Eur J Pharmacol. 2021 May 15;899:174011. doi: 10.1016/j.ejphar.2021.174011. Epub 2021 Mar 9. PMID: 33705803.
[2]. Liu L, Qiu Y, et,al. Genistein Induces Ferroptosis in Colorectal Cancer Cells via FoxO3/SLC7A11/GPX4 Signaling Pathway. J Cancer. 2024 Nov 4;15(20):6741-6753. doi: 10.7150/jca.95775. PMID: 39668836; PMCID: PMC11632993.
Protocol
| Cell experiment [1]: | |
Cell lines | HepG2 cells |
Preparation Method | Cells were cultured in DMEM supplemented with 1% penicillin/streptomycin and 10% FBS, and maintained at 37 ℃ in a humidified atmosphere of 5% CO2. Cells were plated in cell culture flasks for at least 24h before treatment. Batches of cells were seeded in 24-well plates at a density of 2 × 105 cells/well and incubated with various concentrations (10, 50, or 100μM) of JY-2 for 1h, followed by PA (0.5mM) treatment for the indicated time. |
Reaction Conditions | 0.5mM; 24h |
Applications | JY-2 reduces PA-induced lipotoxicity in HepG2 cells. |
| Animal experiment [1]: | |
Animal models | C57BL/6J mice |
Preparation Method | JY-2 (50, 100, 200mg/kg) was orally administered to mice three times for two days (9:00 AM, 7:00 PM, 9:00 AM on the next day), and pyruvate tolerance challenge was carried out after overnight fasting. |
Dosage form | 50, 100, 200mg/kg; p.o; 3 times |
Applications | JY-2 improves glucose intolerance in vivo. |
References: | |
Product Documents
Purity:>99.75%Appearance:A solid
Chemical Properties
CAS No.
339103-05-8
Molecular Formula
C13H7Cl2N3O
Molecular Weight
292.12
Solubility
80mg/mL in DMSO (ultrasonic and warming and heat to 60°C)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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