11-keto Testosterone-d3 is intended for use as an internal standard for the quantification of 11-keto testosterone (CRM) by GC- or LC-MS. 11-keto Testosterone is structurally categorized as an androgen. It is a significant hormone in certain fish, regulating the development of sexual development and behavior.1,2 11-keto Testosterone binds the stickleback kidney androgen receptor (EC50 = 43 nM).3 11-keto Testosterone, at 10 nM, significantly activates the human androgen receptor expressed in zebrafish liver cells.3 This product is intended for research and forensic applications.
1.Yamaguchi, T., Watanuki, H., and Sakai, M.Effects of estradiol, progesterone and testosterone on the function of carp, Cyprinus Carpio, phagocytes in vitroComparative Biochemistry and Physiology129C(1)49-55(2001) 2.Godwin, J.Neuroendocrinology of sexual plasticity in teleost fishesFront.Neuroendocrinol.31(2)203-216(2010) 3.Olsson, P.E., Berg, A.H., von Hofsten, J., et al.Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosteroneReproductive Biology and Endocrinology3:37(2005)