3BP-3580 TFA (compound 11) is a conjugate targeting FAP that binds to FAP-positive cells via the FAPI moiety and internalizes, delivering the payload to FAP -expressing cells, thereby inhibiting RA FLS proliferation, migration, and invasion, reducing inflammatory cytokine expression, and suppressing pannus formation. 3BP-3580 TFA can be used for research on rheumatoid arthritis [1].
References:
[1]. Wang L, et al. Coupled drugs and their preparation methods and their application in the preparation of synovial drugs for the treatment of rheumatoid arthritis. CN116874545A. China. 2023.10.13.
References:
[1]. Wang L, et al. Coupled drugs and their preparation methods and their application in the preparation of synovial drugs for the treatment of rheumatoid arthritis. CN116874545A. China. 2023.10.13.