Adamantan-2-amine (2-Aminoadamantane) serves as the hydrophobic tag structural unit of Tubulin degrader 2 and is used for the synthesis of anticancer drugs that target tubulin via a dual mechanism. Adamantan-2-amine can be applied in research on breast cancer, lung cancer, colorectal cancer, and Parkinson's syndrome [1] [2] [3].
In Vitro, Adamantan-2-amine (2-Aminoadamantane) (0.05 mol; 20 min) hydrochloride successfully undergoes fusion with dicyandiamide at 190°C to produce 1-(2-adamantyl) biguanide hydrochloride with 85% yield[3].
References:
[1]. Wang S, et al. Design, synthesis and biological evaluation of novel tubulin-targeting agents with a dual-mechanism for polymerization inhibition and protein degradation. European journal of medicinal chemistry. 2024 Jun 05;272:116458.
[2]. Morozov IS, et al. Anticataleptic activity of heterocyclic 2-aminoadamantane derivatives. Pharm Chem J. 2000 Apr;34(4):189-192. doi:10.1007/BF02524595.
[3]. Eisa HM, et al. Synthesis of certain 2-aminoadamantane derivatives as potential antimicrobial agents. Die Pharmazie. 1991 Mar;46(3):182-4.
In Vitro, Adamantan-2-amine (2-Aminoadamantane) (0.05 mol; 20 min) hydrochloride successfully undergoes fusion with dicyandiamide at 190°C to produce 1-(2-adamantyl) biguanide hydrochloride with 85% yield[3].
References:
[1]. Wang S, et al. Design, synthesis and biological evaluation of novel tubulin-targeting agents with a dual-mechanism for polymerization inhibition and protein degradation. European journal of medicinal chemistry. 2024 Jun 05;272:116458.
[2]. Morozov IS, et al. Anticataleptic activity of heterocyclic 2-aminoadamantane derivatives. Pharm Chem J. 2000 Apr;34(4):189-192. doi:10.1007/BF02524595.
[3]. Eisa HM, et al. Synthesis of certain 2-aminoadamantane derivatives as potential antimicrobial agents. Die Pharmazie. 1991 Mar;46(3):182-4.